For albinism, healthcare providers advise people to cover up, use sunscreen and avoid excess sunlight to prevent skin cancer. People with albinism also must wear protective sunglasses and, in some cases, prescription corrective lenses. Surgery may be necessary to correct visual impairments.

To treat vitilgo, physicians may prescribe a combination of photo-sensitive medications like trimethylpsoralen and ultraviolet light therapy to darken the spots. If the person has depigmented patches covering more than 50% of the body, doctors also may be able to use skin bleaching agents like monobenzone to give the skin a lighter, more uniform appearance. Other options include cosmetic concealers and skin grafting.

Skin-lightening creams are available for hyper-pigmentation disorders. Doctors also advise staying out of the sun. Counseling with a dietitian may help in cases caused by poor nutrition. For lichen simplex chronicus, doctors could prescribe antihistamines and topical steroid creams to stop the itching. If a mole or birthmark appears suspicious, physicians often will surgically remove it to prevent skin cancer.